AK-7 (C005B-313720)

Catalog No.: C005B-313720
Manufacturer No.: SML0152-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

General description AK-7 (3-(1-azepanylsulfonyl)- N -(3-bromphenyl) benzamide) is a cell- and brain-permeable, selective SIRT2 (sirtuin 2) inhibitor. Application AK-7 has been used in cell culture and cell treatment.

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Description
Specifications

General description

AK-7 (3-(1-azepanylsulfonyl)-N-(3-bromphenyl) benzamide) is a cell- and brain-permeable, selective SIRT2 (sirtuin 2) inhibitor.

Application

AK-7 has been used in cell culture and cell treatment.

Biochem/physiol Actions

In neurons, the sirtuin 2 inhibitor AK-7 is neuroprotective in vitro and decreases polyglutamine inclusions and cholesterol levels. In mice, treatment with brain-permeable SIRT2 inhibitor AK-7 led to improved motor function, extended survival and decreased brain atrophy. AK-7 decreases the polyglutamine aggregation in R6/2 brain.

Selective SIRT2 Inhibitor AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.

AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.

Selective SIRT2 Inhibitor

UPC:: 41101903
Condition:: New
HazmatClass:: No
MPN:: SML0152-5MG
CAS:: 420831-40-9

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