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agk2 (c15-1229-300)

AGK2 >=97% (HPLC) POWDER (C005B-030705)

Catalog No.
C005B-030705
Manufacturer No.
A8231-25MG
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
MG

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Application AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level.

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Application

AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.

Biochem/physiol Actions

AGK2 is a SIRT2 inhibitor. AGK2 rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models. IC50 for SIRT2 = 3.5 uM. AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. AGK2 may be the most selective SIRT2 inhibitor available.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Molecular Weight: 434.27. Empirical Formula: C23H13Cl2N3O2. Quality Level: 100. Assay: ≥. 97% (HPLC). form: powder. solubility: DMSO: 2 . mg/mL, clear (warmed), H2O: insoluble. storage temp.: room temp. SMILES string: Clc1ccc(Cl)c(c1)-c2ccc(\C: C(/C#N)C(: O)Nc3cccc4ncccc34)o2. InChI: 1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+. InChI key: SVENPFFEMUOOGK-SDNWHVSQSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.
UPC:
12141740
Condition:
New
HazmatClass:
No
MPN:
A8231-25MG
CAS:
304896-28-4

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