AFLATOXIN B1 FROM ASPERGILLUS FLAVUS (C005B-009960)

General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Designing Safer Chemicals” and “Design for Energy Efficiency”. Click here to view its DOZN scorecard.

Application

Aflatoxin B1 is a carcinogenic compound that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 may be used as an internal standard when testing for aflatoxin contamination in food products.

Biochem/physiol Actions

Aflatoxin B1 is a carcinogenic compound produced by Aspergillus flavus, a common soil fungus, that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 is a food contaminant and a hepatocarcinogen. Aflatoxin is biotransformed to genotoxic intermediates by P450 Phase I enzymes, mainly CYP3A4 via aflatoxin B1 3-hydroxylation. Detoxification depends on Phase II enzymes, such as Glutathione S-Transferase and AFB(1)-aldehyde reductase (AFAR). Aflatoxin B1 is a CYP1A2, CYP2A6, CYP2D6, and CYP3A family substrate.

Warning

Possibly carcinogenic.

Molecular Weight: 312.27. Empirical Formula: C₁₇H₁₂O₆. biological source: Aspergillus flavus. Quality Level: 300. Assay: ≥. 98.0% (HPLC). form: powder. greener alternative product score: old score: 51
new score: 42
Find out more about DOZNâ„¢ Scoring. greener alternative product characteristics: Waste Prevention
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.. greener alternative category: Re-engineered, . storage temp.: 2-8°C. SMILES string: COc1cc2OC3OC: CC3c2c4OC(: O)C5: C(CCC5: O)c14. InChI: 1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1. InChI key: OQIQSTLJSLGHID-WNWIJWBNSA-N. Pictograms: GHS06,GHS08. Signal Word: Danger. Hazard Statements: H300 + H310 + H330 - H340 - H350 - H361fd. Precautionary Statements: P202 - P260 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310. Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - Carc. 1B - Muta. 1B - Repr. 2. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges.