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ad57

AD57 (C007B-326076)

Catalog No.
C007B-326076
Manufacturer No.
A651331-5mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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AD57 is an orally active multikinase inhibitor, inhibits RET , BRAF , S6K and Src , with greatly reduces mTOR activityIn VitroAD57 (0.2 nM) significantly inhibits the ptc >: dRet MEN2B lethality in the larva of Drosophila. AD57 (0.1 nM) enhances

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AD57 is an orally active multikinase inhibitor, inhibits RET , BRAF , S6K and Src , with greatly reduces mTOR activityIn VitroAD57 (0.2 nM) significantly inhibits the ptc > dRet MEN2B lethality in the larva of Drosophila. AD57 (0.1 nM) enhances survival of ptc > dRet MEN2B by reducing erk gene dosage in Drosophila. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoAD57 inhibits the viability of MEN2B (MZ-CRC-1) and MEN2A (TT) patient-derived cell lines in RET MEN2 models . AD57 (20 mg/kg) significantly inhibits TT-based tumour growth without obvious cytotoxicity in conventional mouse xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Braf.

Specifications and Purity: ≥98%

Molecular Formula: C22H20F3N7O

Molecular Weight: 455.44

UPC:
41113713
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
A651331-5mg
CAS:
1093380-42-7
Product Size:
5mg

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