ACETYLCHOLINE CHLORIDE (C005B-051502)

General description

Acetylcholine is a neurotransmitter released at nerve endings in both the central and peripheral nervous systems. Acetylcholine chloride (C7H16ClNO2) is a stable cholinergic agonist with muscarinic and nicotinic actions. It is available as white or off-white hygroscopic crystals, or as a crystalline powder. Acetylcholine chloride is hygroscopic in nature and is highly soluble in water, alcohol, propylene glycol and chloroform.

Application

Acetylcholine chloride has been used:

• as an agent to trigger sudomotor axon reflex response during autonomic test
• to induce contraction amplitude of pyloric circular smooth muscle strip (PCSMS) in rats
• as a substrate for acetylcholinesterase
• to stimulate after discharge in Aplysia bag cell neurons

Biochem/physiol Actions

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Caution

Very hygroscopic

Molecular Weight: 181.66. Empirical Formula: C₇H₁₆ClNO₂. linearFormula: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-. Quality Level: 200. Assay: ≥. 99% (TLC). mp: 146-150 . °C (lit.). solubility: H₂O: 100 . mg/mL. SMILES string: [Cl-].CC(: O)OCC[N+](C)(C)C. InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4. /h5-6H2,1-4H3. 1H/q+1. /p-1. InChI key: JUGOREOARAHOCO-UHFFFAOYSA-M. Gene Information: human ... CHRM3(1131). Storage Class Code: 11 - Combustible Solids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.