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acetylcholine chloride (c15-1251-607)

ACETYLCHOLINE CHLORIDE CELL CULTURE TESTED (C005B-051500)

Catalog No.
C005B-051500
Manufacturer No.
A2661-25G
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
GR

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Application Acetylcholine chloride has been used in the preparation of acetylcholine, that is used as a common vehicle for iontophoresis of acetylcholine (ACh). It has also been used to treat aNS-1 derived neurons for cAMP (cyclic adenosine

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Application

Acetylcholine chloride has been used in the preparation of acetylcholine, that is used as a common vehicle for iontophoresis of acetylcholine (ACh). It has also been used to treat aNS-1 derived neurons for cAMP (cyclic adenosine monophosphate) assay and also used to check their ability to influence G protein-coupled receptors (GPCRs).

Biochem/physiol Actions

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Molecular Weight: 181.66. Empirical Formula: C7H16ClNO2. linearFormula: (CH3)3N+CH2CH2OCOCH3Cl-. biological source: synthetic. Quality Level: 400. Assay: ~99%. form: powder. technique(s): cell culture | mammalian: suitable. mp: 146-150 . °C (lit.). solubility: water: 100 . mg/mL, clear, colorless. web metadata keyword.default: cholinergic neurotransmitter, cholinergic synapses. shipped in: ambient. storage temp.: room temp. SMILES string: [Cl-].CC(: O)OCC[N+](C)(C)C. InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4. /h5-6H2,1-4H3. 1H/q+1. /p-1. InChI key: JUGOREOARAHOCO-UHFFFAOYSA-M. Gene Information: human ... CHRM3(1131). Storage Class Code: 11 - Combustible Solids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.
UPC:
51151505
Condition:
New
HazmatClass:
No
MPN:
A2661-25G
CAS:
60-31-1

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