ACETAMINOPHEN BIOXTRA (C005B-005173)

General description

Acetaminophen or paracetamol is an analgesic and antipyretic. It is however a weak non opioid analgesic.

Application

Acetaminophen has been used:

• as an anti-inflammatory drug to test its effect in lipid peroxidation in marine mussels
• to test its effect on neurite outgrowth in gamma-aminobutyric acid-ergic and glutamatergic neurons
• as a hepatocellular injury inducing agent in mice

Analgesic.

Biochem/physiol Actions

Acetaminophen or paracetamol is an inhibitor of prostaglandin synthesis. It is complexed with arachidonic acid in central nervous system resulting in the formation of N-arachidonoylphentolamine, which is essential for the activation of cannabinoid receptor. Acetaminophen is metabolized to toxic N-acetyl-p-benzoquinone imine. Paracetamol is prescribed for osteoarthritis pain and inhibits cyclooxygenase 1 and 2 activities. It is metabolized by the cytochrome P450 enzymes in liver and is implicated in liver toxicity.

Molecular Weight: 151.16. Empirical Formula: C₈H₉NO₂. linearFormula: CH₃CONHC₆H₄OH. product line: BioXtra. Quality Level: 200. Assay: ≥. 99.0%. form: powder. impurities: ≤. 0.0005% Phosphorus (P), ≤. 0.1% Insoluble matter. ign. residue: ≤. 0.1%. mp: 168-172 . °C (lit.). solubility: ethanol: 0.5 . M, clear, colorless. anion traces: chloride (Cl^-): ≤. 0.05%, sulfate (SO₄^2-): ≤. 0.05%. cation traces: Al: ≤. 0.0005%, Ca: ≤. 0.0005%, Cu: ≤. 0.0005%, Fe: ≤. 0.0005%, K: ≤. 0.005%, Mg: ≤. 0.0005%, NH₄⁺: ≤. 0.05%, Na: ≤. 0.005%, Pb: ≤. 0.001%, Zn: ≤. 0.0005%. SMILES string: CC(: O)Nc1ccc(O)cc1. InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10). InChI key: RZVAJINKPMORJF-UHFFFAOYSA-N. Gene Information: human ... FAAH(2166), PTGS1(5742), PTGS2(5743), TRPV1(7442). Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H302. Precautionary Statements: P264 - P270 - P301 + P312 - P501. Hazard Classifications: Acute Tox. 4 Oral. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): 364.3 °F - Pensky-Martens closed cup. Flash Point(C): 184.6 °C - Pensky-Martens closed cup. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.