AC-PGP TRIFLUOROACETATE SALT HYDRATE

Biochem/physiol Actions

N-acetyl Proline-Glycine-Proline (ac-PGP) is a potent and selective neutrophil chemoattractant. It is generated enzymatically from extracellular matrix proteins such as collagen. PGP is generated from native collagen by the action of matrix metalloproteinase–8 (MMP-8) and/or MMP-9, followed by a secondary cleavage by prolyl endopeptidase (PE). N-terminal acetylation of PGP (Ac-PGP) occurs through an unknown mechanism. Both PGP and AcPGP are considered biomarkers and possible therapeutic targets for chronic obstructive pulmonary disease (COPD) and may also be markers for acute pulmonary exacerbation in Cystic Fibrosis.

Molecular Weight: 311.33 (anhydrous free base basis). Empirical Formula: C₁₄H₂₁N₃O₅ · xC₂HF₃O₂ · yH₂O. Quality Level: 100. Assay: ≥. 98% (HPLC). form: powder. color: white to tan. solubility: deionized water: ≥. 2 . mg/mL. shipped in: wet ice. storage temp.: −. 20°C. SMILES string: O.OC(: O)C(F)(F)F.CC(: O)N1CCC[C@H]1C(: O)NCC(: O)N2CCC[C@H]2C(O): O. InChI: 1S/C14H21N3O5.C2HF3O2.H2O/c1-9(18)16-6-2-4-10(16)13(20)15-8-12(19)17-7-3-5-11(17)14(21)22. 3-2(4,5)1(6)7. /h10-11H,2-8H2,1H3,(H,15,20)(H,21,22). (H,6,7). 1H2/t10-,11-. . /m0../s1. InChI key: UCOFOXNKITYGTK-ULEGLUPFSA-N. Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H302. Precautionary Statements: P264 - P270 - P301 + P312 - P501. Hazard Classifications: Acute Tox. 4 Oral. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.