ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM ( IC 50 =13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUMIn VitroABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner. ABC99 preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: SW620 cells Concentration: 0.1~10 μΜ Incubation Time: 2 hours Result: Inhibited NOTUM in a concentration-dependent manner.Form:SolidIC50& Target:IC50: 13 nM (Notum).
Specifications and Purity: ≥99%
Molecular Formula: C22H21ClN4O5
Molecular Weight: 456.88
PubChem CID: 134817170
Isomeric SMILES: C1CN2C(CN1CC3=CC=C(C=C3)Cl)C(=O)N(C2=O)OC(=O)N4CCOC5=CC=CC=C54
- UPC:
- 85000000
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A650196-1mg
- CAS:
- 2331255-53-7
- Product Size:
- 1mg
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