9Z,11E,13E-Octadecatrienoic Acid ethyl ester

A conjugated polyunsaturated fatty acid commonly found in plant seed oil which accounts for about 70% in tung oil and 60% of the total fatty acid composition of bitter gourd seed oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC|50|of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC|50|s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.

Specifications and Purity: 10mg/mL in ethanol

Molecular Formula: C20H34O2

Molecular Weight: 306.48

PubChem CID: 12430060

Isomeric SMILES: CCCC/C=C/C=C/C=C/CCCCCCCC(=O)OCC

Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/Z337626-SCI_346c749ccd691c25ab4d44664e850b89.pdf