8-OH-DPAT (8-Hydroxy-DPAT)

Information8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic5-HT1Aagonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous.Targets5-HT1A (Cell-free) 8.19(pIC50)In vitroThe drug is only weakly effective at 5-HT1B subtype, the pIC50 being 5.42 ± 0.08 (n = 5). Since 8-OH-DPAT has no effect on 5-HT1B binding at concentrations lower than 100 nM. 8-OH-DPAT is able to reduce the accumulation of both autophagic-derived and photoreceptor outer segment-derived lipofuscin, increase antioxidant protection and reduce oxidative damage in cultured human RPE cells.In vivoIntravenous administration of the selective 5-HT1A-receptor agonist 8-OH-DPAT rapidly reverses the hypotensive and bradycardic responses established during severe hemorrhage with relatively little variability. 8-OH-DPAT is relatively lipophilic and readily crosses the blood-brain barrier.Cell Research(from reference)Cell lines：Retinal pigment epithelial (RPE) cells Concentrations：10 μM Incubation Time：24 h.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C16H25NO

Molecular Weight: 247.19

PubChem CID: 1220

Isomeric SMILES: CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O