5-FLUOROOROTIC ACID (C005B-024710)

Application

5-Fluoroorotic acid hydrate has also been used as a counter-selection agent to screen L. lactis (multi) peptidase knockout mutants and C. albicans. It has been used in synthesis of 5-fluoroorotidine 5′-monophosphate (FOMP).

Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.

Biochem/physiol Actions

5-Fluoroorotic acid is a selective inhibitor of rRNA synthesis in mammals.

Molecular Weight: 174.09 (anhydrous basis). Empirical Formula: C₅H₃FN₂O₄ · xH₂O. biological source: synthetic. Quality Level: 200. Assay: ≥. 98%. form: powder. technique(s): cell culture | plant: suitable. mp: 278 . °C (dec.) (lit.). solubility: 4 M NH₄OH: 50 . mg/mL, clear, colorless to light yellow. storage temp.: −. 20°C. SMILES string: OC(C(NC(N1): O): C(F)C1: O): O.[H]O[H]. InChI: 1S/C5H3FN2O4.H2O/c6-1-2(4(10)11)7-5(12)8-3(1)9. /h(H,10,11)(H2,7,8,9,12). 1H2. InChI key: LODRRYMGPWQCTR-UHFFFAOYSA-N. Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H302 - H315 - H319 - H335. Precautionary Statements: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338. Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3. Target Organs: Respiratory system. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.