4'-Hydroxy-3'-methoxyacetophenone (C007B-178360)

Apocynin is a methoxy-substituted catechol that is commonly used as an inhibitor of Mox and Nox (NADPH oxidase) (IC50=10 μM). Because of Abocynin's inhibition of NADPH oxidase, ROS production is also inhibited. Studies show the compound's ability to decrease superoxide generation in bovine pulmonary arteries as well as neutrophils and macrophages (10 mM). In experimental rats, apocynin has displayed anti-inflammatory activity and can improve endothelial function by reducing oxidative stress and improved NO bioavailability. Reportedly prevents phagocytosis of MBP (myelin) by macrophages. Also has proven to be a useful product for studying NO-regulated processes in plants.A methoxy-substituted catechol commonly used as an inhibitor of NADPH oxidase.

Specifications and Purity: ≥98%(GC)

MDL Number: MFCD00008747

Molecular Formula: C9H10O3

Molecular Weight: 166.18

PubChem CID: 2214

Isomeric SMILES: CC(=O)C1=CC(=C(C=C1)O)OC

Beilstein Registry Number: 637373

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