4-FLUOROPHENYLMAGNESIUM BROMIDE SOLUTION 1.0 M IN THF

Application

4-Fluorophenylmagnesium bromide solution (Grignard reagent) can be used as a reagent in the synthesis of:

• Useful key intermediate in the synthesis of paroxetine.
• Arylsulfides via cross-coupling reaction with thiols.
• 4-Arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as androgen receptor antagonists.
• Grignard intermediate for preparing aprepitant.

Molecular Weight: 199.30. Empirical Formula: C₆H₄BrFMg. linearFormula: FC₆H₄MgBr. Quality Level: 100. reaction suitability: reaction type: Grignard Reaction. concentration: 1.0 . M in THF. density: 1.021 . g/mL . at 25 . °C. SMILES string: Fc1ccc([Mg]Br)cc1. InChI: 1S/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6. . /h2-5H. 1H. /q. . +1/p-1. InChI key: QYBFFRXNNFXREA-UHFFFAOYSA-M. Pictograms: GHS02,GHS05,GHS07,GHS08. Signal Word: Danger. Hazard Statements: H225 - H302 - H314 - H335 - H336 - H351. Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338. Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B. Supp Hazards: EUH014 - EUH019. Storage Class Code: 3 - Flammable liquids. WGK: WGK 3. Flash Point(F): -4.0 °F - closed cup. Flash Point(C): -20 °C - closed cup. Personal Protective Equipment: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter.