3-Amino-1,2,4-triazole (C007B-021668)

3-Amino-1,2,4-triazole is a small molecule irreversible inhibitor of catalase, an enzyme responsible for converting cellular H2O2 into H2O and O2. Impeding the natural clearance of H2O2 from the cell by catalase has proven useful in studies investigating free radical-mediated damage of cardiac tissue in ischemia. 3-Amino-1,2,4-triazole also shows inhibition of imidazoleglycerol-phosphate dehydratase (HIS3) activity, which interrupts the biosynthesis of histidines. When 3-Amino-1,2,4-triazole is diazotized, the resulting 3-Diazo-1,2,4-triazole is shown to react specifically with tryptophan at acidic pH, presenting a method for determining the tryptophan content of proteins.An irreversible catalase inhibitor.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C2H4N4

Molecular Weight: 84.08

EC Number: 200-521-5

PubChem CID: 1639

Isomeric SMILES: C1=NNC(=N1)N

Beilstein Registry Number: 107687