General description
Rapid palladium-catalyzed carbonylative cyclization reactions of 2-iodophenol with various alkyne under microwave irradiation using Mo(CO)6 as the CO source has been investigated.
Application
2-Iodophenol was used in the synthesis of:
- aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity
- 3,3-disubstituted-2,3-dihydrobenzofurans
Molecular Weight: 220.01. Empirical Formula: C
6H
5IO. linearFormula: IC
6H
4OH. Quality Level: 100. Assay: 98%. form: solid. bp: 186-187 . °C/160 . mmHg (lit.). mp: 37-40 . °C (lit.). density: 1.947 . g/mL . at 25 . °C (lit.). SMILES string: Oc1ccccc1I. InChI: 1S/C6H5IO/c7-5-3-1-2-4-6(5)8/h1-4,8H. InChI key: KQDJTBPASNJQFQ-UHFFFAOYSA-N. Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H302 + H312 + H332 - H315 - H319 - H335. Precautionary Statements: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338. Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3. Target Organs: Respiratory system. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): 235.4 °F - closed cup. Flash Point(C): 113 °C - closed cup. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.