2-CHLORO-2 2-DIFLUOROACETOPHENONE

General description

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem -difluoromethene derived compounds.

Application

2-Chloro-2,2-difluoroacetophenone can be used:

• As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
• As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
• As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.

Molecular Weight: 190.57. Empirical Formula: C₈H₅ClF₂O. linearFormula: C₆H₅COCF₂Cl. Quality Level: 100. Assay: 95%. form: liquid. reaction suitability: reaction type: C-C Bond Formation. refractive index: n20/D 1.4954, n20/D 1.497 (lit.). bp: 94-96 . °C/35 . mmHg (lit.). density: 1.293 . g/mL . at 25 . °C (lit.), 1.3178 . g/mL . at 25 . °C. SMILES string: FC(F)(Cl)C(: O)c1ccccc1. InChI: 1S/C8H5ClF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H. InChI key: MNOONJNILVDLSW-UHFFFAOYSA-N. Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H315 - H319 - H335. Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338. Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3. Target Organs: Respiratory system. Storage Class Code: 10 - Combustible liquids. WGK: WGK 3. Flash Point(F): 160.0 °F. Flash Point(C): 71.1 °C.