2,4'-Dibromoacetophenone (C007B-110901)

GSK-3β Inhibitor VII is a phenyl α-bromomethyl ketone compound which acts as a cell-permeable, and non-ATP competitive inhibitor of glycogen synthase kinases (GSK-3&beta); (IC = 0.5 μM). This compound acts as an alkylating agent that is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM. Research has shown that glycogen synthase kinases have major roles in Wnt and Hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. This pertinent biological activity makes GSK inhibitors very useful research molecules.A cell-permeable, and non-ATP competitive inhibitor of GSK-3βApplication：Undergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.

Specifications and Purity: ≥98%

MDL Number: MFCD00000200

Molecular Formula: C8H6Br2O

Molecular Weight: 277.94

EC Number: 202-783-6

PubChem CID: 7454

Isomeric SMILES: C1=CC(=CC=C1C(=O)CBr)Br

Beilstein Registry Number: 607604

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