17-DMAG - CAS 467214-21-7 - CALBIOCHEM

General description

A cell-permeable, water soluble, potent anti-tumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI₅₀ = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen).

A potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI₅₀ = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility.

Biochem/physiol Actions

Cell permeable: no

GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen

Primary Target
17-DMAG

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tian, Z.Q., et al. 2004. Bioorg. Med. Chem.12, 5317.
Jez, J.M., et al. 2003. Chem. Biol.10, 361.
Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol.49, 7.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 616.75 (free base basis). Empirical Formula: C₃₂H₄₈N₄O₈ · xHCl. Quality Level: 100. Assay: ≥. 95% (TLC). form: solid. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, protect from light. color: purple. solubility: water: 10 . mg/mL, DMSO: 5 . mg/mL. shipped in: wet ice. storage temp.: −. 20°C. InChI: 1S/C32H48N4O8.ClH/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8. /h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40). 1H/b11-9-,19-10+,21-16+. /t18-,20+,25+,26+,28-,30+. /m1./s1. InChI key: DFSYBWLNYPEFJK-IHLRWNDRSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.