Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the human recombinant IP and EP receptors with a Ki of 11 nM. 15(R)-Iloprost is the “unnatural” or inverted C-15 epimer of iloprost. This transformation frequently attenuates the biological agonist activity of prostaglandin analogs by several orders of magnitude. There are no literature reports of the biological activity of 15(R)-iloprost.
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- UPC:
- 51131507
- HazmatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- 10043-5
- CAS:
- 85026-51-3
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