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1-deoxynojirimycin hydrochloride (c15-1260-103)

1-DEOXYNOJIRIMYCIN HYDROCHLORIDE (C005B-059181)

Catalog No.
C005B-059181
Manufacturer No.
D9305-10MG
Manufacturer Name
Sigma-Aldrich
Quantity
10
Unit of Measure
MG

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Chemical structure: glucosamine Application 1-Deoxynojirimycin hydrochloride has been used to study its effects on the loss-of-function of N-glycosylation pathway on hair cell regeneration as an endoplasmic reticulum (ER) α-glucosidase I

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General description

Chemical structure: glucosamine

Application

1-Deoxynojirimycin hydrochloride has been used

  • to study its effects on the loss-of-function of N-glycosylation pathway on hair cell regeneration
  • as an endoplasmic reticulum (ER) α-glucosidase I and II inhibitor to study its effects on TMED3-cystic fibrosis transmembrane conductance regulator (CFTR) interaction
  • as an insect trehalase inhibitor in TREH inhibition bioassay

Biochem/physiol Actions

1-Deoxynojirimycin (DNJ) is a naturally occurring alkaloid azasugar or iminosugar. It is observed in mulberry leaves, Commelina communis, and bacterial strains including Bacillus and Streptomyces species. DNJ acts as an α-glucosidase inhibitor and exhibits anti-viral anti-diabetic, anti-inflammatory, anti-obesity, and antioxidant properties.

α-Glucosidase inhibitor

Molecular Weight: 199.63. Empirical Formula: C6H13NO4 · HCl. Assay: ≥. 98% (TLC). Quality Level: 200. form: powder. solubility: water: 19.60-20.40 . mg/mL, clear, colorless. antibiotic activity spectrum: viruses. Mode of action: enzyme | inhibits. storage temp.: 2-8°C. SMILES string: Cl[H].OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O. InChI: 1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3. /h3-11H,1-2H2. 1H/t3-,4+,5-,6-. /m1./s1. InChI key: ZJIHMALTJRDNQI-VFQQELCFSA-N. Gene Information: human ... GAA(2548). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).
UPC:
51111707
Condition:
New
HazmatClass:
No
MPN:
D9305-10MG
CAS:
73285-50-4

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