(1 3-DIOXOLAN-2-YLMETHYL)MAGNESIUM BROMIDE 0.5M SOLUTION IN THF (C005B-022636)

Application

(1,3-Dioxolan-2-ylmethyl)magnesium bromide is a Grignard reagent that can be used to prepare:

• 3-[¹¹C]-Propionaldehyde, a key intermediate for the synthesis of radiolabeled compound [¹¹C]SN-38, wherein SN-38 is 7-ethyl-10-hydroxy camptothecin.
• 1-[(S)-2,2-Dimethyl-(1,3)-dioxolan-4-yl]-4-(1,3-dioxolan2-yl)-2-ol by reacting with D-glyceraldehyde, which is further used to synthesize unsaturated nucleosides.
• A bicyclo carboxylate intermediate, which is employed in the total synthesis of spirovibsanin A.

Molecular Weight: 191.31. Empirical Formula: C₄H₇BrMgO₂. reaction suitability: reaction type: Grignard Reaction. Quality Level: 100. concentration: 0.5 . M in THF. bp: 65-67 . °C. density: 0.938 . g/mL . at 25 . °C. SMILES string: Br[Mg]CC1OCCO1. InChI: 1S/C4H7O2.BrH.Mg/c1-4-5-2-3-6-4. . /h4H,1-3H2. 1H. /q. . +1/p-1. InChI key: ZDNTZRAFJZERSL-UHFFFAOYSA-M. Pictograms: GHS02,GHS05,GHS07,GHS08. Signal Word: Danger. Hazard Statements: H225 - H302 - H314 - H335 - H336 - H351. Precautionary Statements: P201 - P210 - P280 - P303 + P361 + P353 - P305 + P351 + P338 + P310 - P308 + P313. Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B. Supp Hazards: EUH018 - EUH019. Storage Class Code: 3 - Flammable liquids. WGK: WGK 3. Flash Point(F): 1.4 °F - closed cup. Flash Point(C): -17 °C - closed cup. Personal Protective Equipment: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter.