Neurological discriminators

Application MST-312 has been used in cell invasion assay using mouse fibroblast cells (NIH-3T3) and in the co-immunoprecipitation experiments in colon fibroblast. Biochem/physiol Actions MST-312 is a telomerase Inhibitor.

Biochem/physiol Actions NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development.

General description PD 169316 is a pyridinyl imidazole compound. It is a potential inhibitor of p38 mitogen-activated protein kinases.

General description PD 169316 is a pyridinyl imidazole compound. It is a potential inhibitor of p38 mitogen-activated protein kinases.

General description RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality.

Biochem/physiol Actions BCI-121 is a substrate-competitive SMYD3 inhibitor that reduces nuclear histone H3 lys4 di- and tri-methylation level (by 50%/H3K4me2 and 40%H3K4me3 in HT29 cells: 100 &#956:M BCI-121 for 48 h), downregulates known SMYD3

Biochem/physiol Actions BCI-121 is a substrate-competitive SMYD3 inhibitor that reduces nuclear histone H3 lys4 di- and tri-methylation level (by 50%/H3K4me2 and 40%H3K4me3 in HT29 cells: 100 &#956:M BCI-121 for 48 h), downregulates known SMYD3

Biochem/physiol Actions ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity. Adenylyl cyclase 1 has been shown to be a potential target for treating pain and reducing the dependency on opioids, but it has been

Biochem/physiol Actions ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity. Adenylyl cyclase 1 has been shown to be a potential target for treating pain and reducing the dependency on opioids, but it has been

Biochem/physiol Actions BD064 is a probe-dependent and biased negative allosteric modulator (NAM) of the chemokine receptor CXCR3 signaling that preferentially inhibits CXCL11-mediated ?-arrestin 2 recruitment over G protein activation.

Biochem/physiol Actions BD064 is a probe-dependent and biased negative allosteric modulator (NAM) of the chemokine receptor CXCR3 signaling that preferentially inhibits CXCL11-mediated ?-arrestin 2 recruitment over G protein activation.

Biochem/physiol Actions MS417, a (+)-JQ1 analog, is a potent inhibitor of bromodomain-containing protein 4 (BRD4) that is highly specific for BRD4-BD1 and BRD4-BD2. MS417 binds with similar affinity to BRD4-BD1 and BRD4-BD2 (Kd =36.