A full antagonist of RXR that demonstrates potent, nanomolar binding affinity does not affect the corepressor interaction capacity of the RAR&alpha subunit in the RAR-RXR heterodimer configuration.
A full antagonist of RXR that demonstrates potent, nanomolar binding affinity does not affect the corepressor interaction capacity of the RAR&alpha subunit in the RAR-RXR heterodimer configuration.
An immunomodulatory compound that inhibits inflammatory antigen presentation both in vitro and in preclinical in vivo models of autoimmune diseases targets macrophages, reducing the production of the proinflammatory mediators TNF-&alpha,
An immunomodulatory compound that inhibits inflammatory antigen presentation both in vitro and in preclinical in vivo models of autoimmune diseases targets macrophages, reducing the production of the proinflammatory mediators TNF-&alpha,
Antigen: synthetic peptide from human FABP3 amino acids 44-55 Host: mouse Cross Reactivity:(+) human and rat FABP3, (&minus) mouse FABP3, other species not tested Application(s): WB (1:200 dilution) other applications not tested
Antigen: synthetic peptide from human FABP3 amino acids 44-55 Host: mouse Cross Reactivity:(+) human and rat FABP3, (&minus) mouse FABP3, other species not tested Application(s): WB (1:200 dilution) other applications not tested
A selective inhibitor of diacylglycerol lipase (IC<sub>50</sub> = 4 µM) that demonstrates relatively weak inhibition of phospholipases A2 and C elevates the concentration of diacylglycerol, which leads to activation of PKC.
A selective inhibitor of diacylglycerol lipase (IC<sub>50</sub> = 4 µM) that demonstrates relatively weak inhibition of phospholipases A2 and C elevates the concentration of diacylglycerol, which leads to activation of PKC.
A non-steroidal androgen receptor antagonist (IC50 = 36 nM) reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.
A non-steroidal androgen receptor antagonist (IC50 = 36 nM) reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.
A selective inhibitor of NUAK1 and NUAK2 (IC<sub>50</sub>s = 20 and 100 nM, respectively) inhibits the phosphorylation of the NUAK1 substrate MYPT1 at Ser445 inhibits proliferation and migration of mouse embryonic fibroblasts and U2OS cells at 10
A selective inhibitor of NUAK1 and NUAK2 (IC<sub>50</sub>s = 20 and 100 nM, respectively) inhibits the phosphorylation of the NUAK1 substrate MYPT1 at Ser445 inhibits proliferation and migration of mouse embryonic fibroblasts and U2OS cells at 10