Beta gamma counters

CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.

InformationBI-1347 BI-1347 is small molecule inhibitor of Cyclin-dependent kinase 8(CDK8) with IC50 of 1.1 nM.TargetsCDK8 (Cell-free assay) 1.1 nM.

InformationBI-1347 BI-1347 is small molecule inhibitor of Cyclin-dependent kinase 8(CDK8) with IC50 of 1.1 nM.TargetsCDK8 (Cell-free assay) 1.1 nM.

InformationBI-1347 BI-1347 is small molecule inhibitor of Cyclin-dependent kinase 8(CDK8) with IC50 of 1.1 nM.TargetsCDK8 (Cell-free assay) 1.1 nM.

InformationBetahistine (PT-9) is ahistamine H3receptor inhibitor withIC50of 1.9 μM.In vitroBetahistine progressively enhances cAMP formation with a maximal effect, observed up to 10 nM, in CHO(H3R) cells incubated with 3 μM forskolin. In contrast,

Gamma-BHC solution.

Gamma-BHC solution.

Gamma-BHC solution.

Gamma-BHC solution.

Potent and selective TRPM8 antagonist: activein vivo.

InformationA-381393 is a potent, selective, brain-penetrate antagonist of dopamine D4 receptor with Ki of 1.5 nM, 1.9 nM and 1.6 nM for human dopamine D4.4, D4.2 and D4.7 receptor, respectively. A-381393 shows moderate affinity for 5-HT2A with Ki of

InformationA-381393 is a potent, selective, brain-penetrate antagonist of dopamine D4 receptor with Ki of 1.5 nM, 1.9 nM and 1.6 nM for human dopamine D4.4, D4.2 and D4.7 receptor, respectively. A-381393 shows moderate affinity for 5-HT2A with Ki of