InformationSRT2104 (GSK2245840) is a selectiveSIRT1activator involved in the regulation of energy homeostasis. Phase 2.TargetsSIRT1In vitroSRT2104 reduces p65/RelA acetylation levels in C2C12 cells.In vivoIn male C57BL/6J mice, SRT2104 (100 mg/kg,
InformationSRT2104 (GSK2245840) is a selectiveSIRT1activator involved in the regulation of energy homeostasis. Phase 2.TargetsSIRT1In vitroSRT2104 reduces p65/RelA acetylation levels in C2C12 cells.In vivoIn male C57BL/6J mice, SRT2104 (100 mg/kg,
InformationSRT2104 (GSK2245840) is a selectiveSIRT1activator involved in the regulation of energy homeostasis. Phase 2.TargetsSIRT1In vitroSRT2104 reduces p65/RelA acetylation levels in C2C12 cells.In vivoIn male C57BL/6J mice, SRT2104 (100 mg/kg,
InformationSRT2104 (GSK2245840) is a selectiveSIRT1activator involved in the regulation of energy homeostasis. Phase 2.TargetsSIRT1In vitroSRT2104 reduces p65/RelA acetylation levels in C2C12 cells.In vivoIn male C57BL/6J mice, SRT2104 (100 mg/kg,
InformationSRT2104 (GSK2245840) is a selectiveSIRT1activator involved in the regulation of energy homeostasis. Phase 2.TargetsSIRT1In vitroSRT2104 reduces p65/RelA acetylation levels in C2C12 cells.In vivoIn male C57BL/6J mice, SRT2104 (100 mg/kg,
InformationSRT2104 (GSK2245840) is a selectiveSIRT1activator involved in the regulation of energy homeostasis. Phase 2.TargetsSIRT1In vitroSRT2104 reduces p65/RelA acetylation levels in C2C12 cells.In vivoIn male C57BL/6J mice, SRT2104 (100 mg/kg,
InformationSNS-314 is a potent and selective inhibitor ofAurora A,Aurora BandAurora CwithIC50of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.In vitroIn HCT116 colorectal carcinoma cell
InformationSNS-314 is a potent and selective inhibitor ofAurora A,Aurora BandAurora CwithIC50of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.In vitroIn HCT116 colorectal carcinoma cell
Ibrutinib is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.
Ibrutinib is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.