An antagonist of OX2R (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with OX1R (IC<sub>50</sub>s = 40 nM and >10,000 nM, respectively.
An antagonist of OX2R (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with OX1R (IC<sub>50</sub>s = 40 nM and >10,000 nM, respectively.
Inhibits KDR and Flt VEGF receptors with IC<sub>50</sub> values of 100 nM and 2 &muM, respectively also inhibits EGFR kinase (IC<sub>50</sub> < 10 nM), reducing proliferation of EGFR-dependent cancer cells.
Inhibits KDR and Flt VEGF receptors with IC<sub>50</sub> values of 100 nM and 2 &muM, respectively also inhibits EGFR kinase (IC<sub>50</sub> < 10 nM), reducing proliferation of EGFR-dependent cancer cells.
An inhibitor of PHGDH, inhibiting serine synthesis from 3-PG in cells (IC<sub>50</sub> = 33 µM) inhibits the proliferation of cancer cells by blocking de novo serine synthesis.
An inhibitor of PHGDH, inhibiting serine synthesis from 3-PG in cells (IC<sub>50</sub> = 33 µM) inhibits the proliferation of cancer cells by blocking de novo serine synthesis.
A selective TRPA1 blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal (IC<sub>50</sub>s = 14.3 and 18.
A selective TRPA1 blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal (IC<sub>50</sub>s = 14.3 and 18.
A trichothecene mycotoxin that can infect grain crops causing alimentary toxic aleukia in humans and animals inhibits protein synthesis, disrupts membrane phospholipid metabolism, increases lipid peroxides in the liver, and is highly cytotoxic to
A trichothecene mycotoxin that can infect grain crops causing alimentary toxic aleukia in humans and animals inhibits protein synthesis, disrupts membrane phospholipid metabolism, increases lipid peroxides in the liver, and is highly cytotoxic to
A calcium-dependent activator of BKCa channels that is typically used at a concentration of 30 µM to hyperpolarize the membrane potential of single myocytes during studies of smooth muscle relaxation and vasodilation cardioprotective against
A calcium-dependent activator of BKCa channels that is typically used at a concentration of 30 µM to hyperpolarize the membrane potential of single myocytes during studies of smooth muscle relaxation and vasodilation cardioprotective against
Equinox analytical balances deliver remarkable precision to labs that perform highly detailed testing. The Equinox is ideal for research and quality assurance facilities science education precision counting and production and manufacturing
Equinox analytical balances deliver remarkable precision to labs that perform highly detailed testing. The Equinox is ideal for research and quality assurance facilities science education precision counting and production and manufacturing