Cell metabolism analyzer accessories

The mechanism for the movement of cholesterol from intracellular sites to their ultimate cellular destination is an unresolved question of fundamental importance to cell biology and medicine. Thus, defining mechanisms of intracellular cholesterol

A selective inhibitor of RIP1.

A selective, brain penetrant EP2 antagonist (KB = 2.4 nM) blocks the induced expression of inflammatory markers in microglial cells treated with butaprost reduces neurodegeneration in a mouse model of status epilepticus inhibits proliferation and

Mitochondrial membrane potential, &Delta&psim, is an important parameter of mitochondrial function that is used as an indicator of cell health. JC-1 is a lipophilic, cationic dye that can selectively enter into mitochondria and reversibly change

A potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3K&alpha (IC50 = 2 nM) and the common activating mutants of p100&alpha (E542K, E545K, and H1047R) found in cancer prevents proliferation in BT474 tumor xenografts and reduces

Maintaining body cholesterol homeostasis is critical for normal physiological functions and is achieved by a highly regulated balance of de novo synthesis, dietary cholesterol absorption, biliary clearance, and excretion. The mechanisms controlling

When measuring mitochondrial function or the effects of an unknown on mitochondrial function, it can be difficult to determine a mechanism using whole organisms or tissue. When this is the case, isolated mitochondria provide a simple and

A small molecule inhibitor of JAK2 (IC₅₀ = 6 nM) and the related kinases FLT3 (IC₅₀ = 25 nM) and RET (IC₅₀ = 17 nM) with significantly less potent activity against JAK3 (IC₅₀ = 169 nM) inhibits the growth

Cayman&rsquos CFSE Cell Division Assay Kit provides an easy-to-use format for labeling and tracing cells through successive cell divisions. Carboxyfluorescein diacetate, succinimidyl ester (CFDA-SE) diffuses into cells, where the acetate groups are

A &beta-lactone that stimulates host defense in immune cells by inhibiting cell surface esterases, lipases, and N-formylmethionine aminopeptidases with IC₅₀ values of 0.056, 0.

A selective agonist of FXR (EC50 = 15 nM) displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 &muM.

A 2-thio-dimethoxy naphthoquinone analog that blocks Snail binding to p53 and induces p53 expression in cancer cells in a K-Ras dependent manner.