Conjugated nucleotides or oligomers

The immediate precursor of melatonin that is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and converted to melatonin by acetylserotonin O-methyltransferase acts as an agonist at the melatonin receptors MT1, MT2, and MT3.

Each vial contains nNOS (rat) to be used as a standard for WB and electrophoresis. The enzyme has been carefully purified to exclude all unrelated proteins may not be catalytically active.

Each vial contains 5 &microg of iNOS (murine macrophage) to be used as a standard for WB and electrophoresis. The enzyme has been carefully purified to exclude all unrelated proteins may not be catalytically active.

A potent inhibitor of calcium release-activated calcium channels in lymphocytes (IC₅₀ = 100 nM) also inhibits lung IL-4 and CysLT generation in animal models of asthma.

A selective ALK2 inhibitor (IC₅₀ = 1.3 nM) that less potently inhibits ALK1 and ALK3 (IC₅₀ = 2.

Inhibits BMP type 1 receptor-induced phosphorylation of SMAD1/5/8 (IC50 = 4.9 nM) shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively).

A calcium-dependent activator of BKCa channels that is typically used at a concentration of 30 &microM to hyperpolarize the membrane potential of single myocytes during studies of smooth muscle relaxation and vasodilation cardioprotective against

A reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a Ki of 12.8 nM less potently blocks activation of GPR35 by zaprinast (IC50 = 160 nM) shows ~57-fold selectivity for GPR35 over the

A metabolite of dapsone, an anti-inflammatory and antibacterial compound that is widely used in the treatment of leprosy, malaria, acne, and various immune disorders.

A selective inhibitor of PKC-induced NF-&kappaB pathway activation (IC₅₀ = 0.07 &muM) inhibits IL-8 production in HEK293 cells (IC₅₀ &le 0.

A specific suicide substrate for CYP2C9 and CYP2C10 whereby its oxidation inactivates CYP2C10 with a t&frac12max of 3.4 minutes and a KI value of 4.3 &microM.

A selective small molecule inhibitor of PKD (IC₅₀s = 182, 280, 227 nM for PKD1, 2, and 3, respectively) 25 &microM has been shown to inhibit prostate cancer cell proliferation, cell migration, and invasion.