Sodium apolate

A fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides displays high affinity for L-FABP (K_i = 24 nM) exhibits EC₅₀ values of 18 and 30 &microM for murine and human

An orally bioavailable inhibitor of ALK (IC₅₀ &lt 100 nM in Ba/F3 cells) a pan-ALK inhibitor that also inhibits several ALK mutants that confer resistance to other ALK inhibitors.

A diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant has anti-fungal activities and diverse effects that are relevant to cancer therapy.

A small molecule enolase inhibitor.

An antioxidant and free radical scavenging compound extracted from S. miltiorrhiza that has been investigated for its cardioprotective and chemopreventative properties.

1-Hexadecyl lysophosphatidic acid is an ether analog of LPA containing a hexadecyl group at the sn-1 position. LPA binds to five different GPCRs to mediate a variety of biological responses including cell proliferation, smooth muscle contraction,

The biology of highly reactive oxygen radical species is of great interest in many biomedical research disciplines, including, neurodegeneration and aging, cancer, and infectious diseases. There are a number of fluorescent reagents that can be used

A 26-carbon saturated (26:0) fatty acid elevated plasma levels of hexacosanoic acid are found in peroxisomal disorders increased levels of hexacosanoic acid may also be associated with atherosclerosis and metabolic syndrome.

A ribonucleotide reductase inhibitor and iron chelator with antitumor activity inhibits DNA synthesis and repair by destroying the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase through the formation of a redox active

Valeroyl salicylate is a selective, irreversible inhibitor of COX-1. The IC₅₀ values for ovine COX-1 and -2 are 0.

HDAC1 and HDAC3 inhibitor (ID50 = 0.01 and 0.07 &muM, respectively, in vitro) induces apoptosis in nine different neuroblastoma cell lines in culture (0.5-4.0 &muM) and completely suppresses neuroblastoma tumor growth in SCID mice at 200 mg/kg.

An inhibitor of USP14 and UCHL5, two proteasome-associated deubiquitinases inhibits DUB activity in purified 19S proteasomes with an IC50 value of 2.1 &microM blocks tumor progression in vivo in mice and prevents organ infiltration in mouse