Combination chlorpheniramine acetaminophen

A commonly used NO donor and a potent vasodilator.

A sulfide-like inhibitor of PDE7 (IC₅₀ = 2.1 &microM).

A prostacyclin analog that is orally active with prolonged availability in vivo, having a terminal half-life in plasma of one hour inhibits the pro-inflammatory actions of certain leukocytes, suppresses cardiac fibrosis, and blocks mitogenesis of

An orally available, selective inhibitor of ALK (IC₅₀ = 1.9 nM) that also inhibits F1174L, R1275Q, and L1196M mutants of ALK (IC₅₀s = 1.

A commonly used NO donor and a potent vasodilator.

A sulfide-like inhibitor of PDE7 (IC₅₀ = 2.1 &microM).

Increases the activity of angiotensin-converting enzyme 2 (ACE2) in vitro (EC50 = 19.5 &muM).

An inhibitor of Nampt and NF-&kappaB pathway activity potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.

A major metabolite of histamine used as a biomarker of histaminergic system activity.

A potent, cell permeable inhibitor of PKC (IC50 = 660 nM) also inhibits BclXL function (IC50 = 1.5 &muM), inducing apoptosis in several cancer cell lines can have PKC-independent effects, activate p38 and JUNK signaling pathways, and induce

A prodrug for 5-ASA, which is effective against Crohn&rsquos disease and ulcerative colitis in animal models and clinical trials.

A synthetic analog of retinoic acid that binds to retinoic acid receptors with similar efficiency as retinoic acid (Kis in the nM range) yet does not display affinity for cellular retinoic acid-binding protein (Ki = 540 &microM).