akash.verma@cenmed.com
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11320-10A mycotoxin found as food contaminants that causes mycotoxic nephropathy in livestock and Balkan nephropathy and yellow rice fever in humans induces apoptosis, blocks tubulin polymerization, and disrupts mitotic spindle assembly. -
18227-10A corticosteroid prodrug that is converted to its active form, des-CIC, a glucocorticoid receptor agonist (Ki = 0.31 nM) used to ameliorate symptoms of airway inflammatory diseases. -
16042-25A calcimimetic that allosterically activates the calcium-sensing receptor (CaSR pEC<sub>50</sub> = 7.3 in HEK293T cells expressing CaSR) inhibiting parathyroid hormone secretion. -
18738-100A model nucleobase that is used to study DNA interactions with organometallic complexes, especially those designed to target tumors. -
11988-10A partial receptor agonist of mGlu4, effective at 100 µM, with no activity at other mGlu receptor subtypes induces apoptosis of T cells at 300-500 µM. -
16147-25An essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism the pantothenate kinase step of the coenzyme A biosynthetic pathway has been identified as a target for the -
11320-5A mycotoxin found as food contaminants that causes mycotoxic nephropathy in livestock and Balkan nephropathy and yellow rice fever in humans induces apoptosis, blocks tubulin polymerization, and disrupts mitotic spindle assembly. -
17757-1A selective inhibitor of the stress-induced PPP1R15A that does not affect the constitutive PPP1R15B 50 µM prolongs eIF2&alpha phosphorylation after ER stress, delaying translation which protects cells from misfolded protein-induced -
17468-1An activator of sGC that binds to a regulatory site, resulting in activation in an NO-independent manner (Kd = 3.2 nM) reduces hypertension, limits cardiomyocyte hypertrophy, protects against ischemia/reperfusion injury, and reduces morbidity and -
18738-50A model nucleobase that is used to study DNA interactions with organometallic complexes, especially those designed to target tumors. -
10005002-1A nutlin-3 analog inhibits the growth of HCT116 cells at high concentrations (IC50 = ~8 µM) promotes the growth of HCT116 cells ~40% at concentrations between 5-100 nM. -
10004985-1A nutlin-3 analog inhibits the growth of HCT116 cells at high concentrations (IC50 = ~7 µM) promotes the growth of HCT-116 cells ~20% at concentrations at or below 1 µM.
