Antidiarrheals

The optically active enantiomer of fluprostenol.

?8-Hydroxy-2&#39-deoxyguanosine is produced by oxidative damage of DNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a marker of oxidative stress in biological systems.

A fluorescently-labeled fructose derivative that specifically accumulates in cells bearing GLUT5 transporters and is used to monitor fructose uptake in normal and cancerous cells via fluorescent microscopy.

A natural alkaloid mycotoxin that blocks activation of the HIV LTR by TNF-&alpha in HeLa cells (IC₅₀ = 5 &microM) inhibits virus production in OM-10.1 cells (HL-60 promyelocytes infected with HIV-1) treated with TNF-&alpha

An inhibitor of MTTP (IC50 = 8 nM in vitro) that has been shown to reduce the production of apolipoprotein B, thereby lowering LDL cholesterol levels, in both preclinical and clinical homozygous familial hypercholesterolemia studies.

CAS Number: 1173020-43-3 Synonyms: LY110140-d₅ Molecular Formula: C₁₇H₁₃D₅F₃NO &bull HCl Formula Weight: 350.8

An autophagy inhibitor, inducing cell death in human breast cancer Bcap-37 cells grown in glucose-free media (EC₅₀ = ~1.25 &microM) promotes the degradation of Vps34 PI3K complex by inhibiting the deubiquitinating enzymes USP10 and

An sGC stimulator that increases the activity of sGC in vitro by up to 73-fold and acts in synergy with nitric oxide to increase sGC activity up to 122-fold promotes vasodilation in several pre-clinical animal models of hypertension and has been

The optically active enantiomer of fluprostenol.

The major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 isoforms CYP1A2 and CYP3A4 inhibits the binding of testosterone to the nuclear androgen receptor (IC₅₀ = ~300-900), blocking

An inhibitor of MTTP (IC50 = 8 nM in vitro) that has been shown to reduce the production of apolipoprotein B, thereby lowering LDL cholesterol levels, in both preclinical and clinical homozygous familial hypercholesterolemia studies.

A selective estrogen receptor modulator that exhibits estrogenic activity in bone cells without stimulating breast or endometrial tissue.