Sodium thiosalicylate

A chromogenic PLA2 substrate that contains a palmitoyl thioester at the sn-2 position of the glycerol backbone.

A VCP inhibitor (IC₅₀ = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC₅₀s &gt10 &muM). It has been shown to inhibit the

An analog of AEA in which the alcohol of the ethanolamide group has been replaced with a fluorine atom, which increases the binding affinity and selectivity for the CB1 receptor (Ki = 5.7 nM in rat brain) in vivo activity is enhanced much less than

A chromophoric substrate that is used to quantify inorganic phosphate (Pi) in the presence of purine nucleoside phosphorylase, followed by continuous spectrophotometry at an absorbance of 355-360 nm used to measure changes in Pi levels in coupled

A potent and selective competitive inhibitor of nNOS (Ki = 57 nM bovine) exhibits 3,000-fold and 150-fold selectivity for the neuronal isoform versus the inducible (murine Ki = 180 &microM) and endothelial (bovine Ki = 8.5 &microM) isoforms of

A phospholipid containing palimitoyl (16:0) and oleoyl (18:1) acyl substituents at the sn-1 and sn-2 positions, respectively, that been used to generate lipid membrane bilayers with controlled permeability and may be useful for various surfactant

A synthetic intermediate useful for pharmaceutical synthesis.

An endogenous biogenic amine commonly found in invertebrates similar to norepinephrine in structure and action in invertebrates considered a trace amine which may interfere with aminergic pathways in humans.

A nucleoside analog that is incorporated into de novo-synthesized telomeres by telomerase induces telomerase dysfunction resulting in telomeric DNA damage and rapid cell death.

A specific adenosine A2 receptor agonist with antipyretic and anticonvulsant activity stimulates the production of cyclic AMP in CHO-K1 cells with an EC₅₀ value of 5.3 &microM.

A first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50s = 5.2 and 82 nM, respectively).

An uncommon phospholipid having the &omega-3 fatty acid docosahexaenoate (DHA) in the sn-2 position releases an unusual DHA-containing DAG in response to PLC and can serve as a source of DHA in response to PLA2 can serve as an anchor for the