Sodium thiosalicylate

A 3-furyl arachidonoyl analog that acts as a potent and selective reuptake inhibitor of AEA (IC50 = 0.8 &microM) but has low affinity for FAAH (IC50 = 30 &microM) potentiates the biological effects of AEA when co-administered in rats.

A form of the sugar Neu5Ac O-linked with the nucleotide CMP serves as the substrate for sialyltransferases, which transfer Neu5Ac from CMP-sialic acid to various acceptor substrates, most commonly at terminal positions of the oligosaccharide

A tumor-promoting teleocidin compound that activates PKC (Ki = 3.4 nM and 1 &muM for PKC&eta and PKC&gamma, respectively) induces differentiation of human embryonic stem cells into pancreatic progenitors.

An inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7.5

A serine proteases inhibitor that is capable of inhibiting trypsin (a digestive system protease Ki = 15 nM), tryptase (a mast cell protease Ki = 95.3 pM), and additional proteases in the coagulation cascade including thrombin (Ki = 0.

A nucleoside analog that is incorporated into de novo-synthesized telomeres by telomerase induces telomerase dysfunction resulting in telomeric DNA damage and rapid cell death.

An anti-migraine agent.

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against is chemia-reperfusion injury in animal heart, liver, and kidney models.

Thioarginine (hydrobromide) is a colorimetric substrate for arginase that provides the basis for continuous spectrophotometric measurement of enzyme activity. It exhibits Km and kcat values of 0.

A monosialoganglioside that demonstrates both antiproliferative and antiangiogenic effects in tumor cells dissociates the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing

A functionally selective inhibitor of Chk1 (Kd = 2 nM IC₅₀ = 3 nM) interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells.

A thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity used as a chemotherapeutic for acute leukemia and other types of cancer,