Carbidopa

An inhibitor of PD-1/PD-L1 interaction.

A natural 20:0 ceramide that is abundant in the brain synthesized de novo by ceramide synthases 1 and 2.

A selective allosteric inhibitor of Bcr-Abl (IC₅₀s = 4.52, 0.

A benzoylguanidine compound that selectively inhibits NHE-1 (IC₅₀s range from 0.03-3.4 &microM).

An alkaloid originally found to have antimicrobial actions both 5-LO and COX-2 (IC₅₀s = 600 and 64 nM, respectively) suppresses angiogenesis, blocking signaling through VEGFR2 at the level of ERK1/2 signaling prevents ERK signaling

A synthetic PAF analog which contains an ether-linked methyl group at the sn-2 position decreases plasma membrane fluidity, inhibits tumor cell invasiveness, and causes the release of large quantities of NO by a pathway involving activation of NOS.

An antimicrotubule drug used to treat Hodgkin&rsquos lymphoma, non-small cell lung, breast, head and neck, and testicular cancer inhibits steady-state tubulin addition to microtubules (Ki = 0.18 &muM) and inhibits B16 melanoma cell proliferation

An agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively) alters hemodynamic properties, including hypertension, in animals.

A selective, cell-permeable inhibitor of calpains (Ki = 0.21 &muM for &mu-calpain (calpain-1) and 0.37 &muM for m-calpain (calpain-2)).

An indole plant alkaloid used as a peripheral vasodilator to increase blood flow to the brain contracts excised human cerebrovascular smooth muscle in vitro with an EC50 value of 30 &muM.

An analog of L-carnitine that, in the range of 0.25-1 mM, inhibits the uptake of L-carnitine by cells.

An alkaloid originally found to have antimicrobial actions both 5-LO and COX-2 (IC₅₀s = 600 and 64 nM, respectively) suppresses angiogenesis, blocking signaling through VEGFR2 at the level of ERK1/2 signaling prevents ERK signaling