Carbidopa

An intermediate aldehyde metabolite of losartan that does not block angiotensin receptors, but instead inhibits COX-2 expression, blocks ICAM-1 mRNA upregulation, and COX-dependent generation of TXA2 and PGF2&alpha also acts as a partial agonist

An allosteric inhibitor of oncogenic K-Ras(G12C).

A synthetic heptapeptide that acts as a specific substrate for PKA.

A protopanaxadiol that has diverse in vitro and in vivo effects, including cardioprotective, neuroprotective, and anti-inflammatory actions.

A natural 3-O-galactoside of quercetin that has powerful antioxidant action through its ability to scavenge free radicals (IC₅₀s = 3.54 and 5.44 &microg/ml in ABTS and DPPH assays, respectively).

An inhibitor of ALK with an IC₅₀ value of 200 pM in enzymatic assays inhibits ALK in cells (IC₅₀ = 25 nM) and in vivo, producing tumor regression in a rat xenograft model.

2-O-methyl PAF C-16 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the sn-2 position. Although the biological activities of 2-O-methyl PAF C-16 have not been well characterized, the C-18 analog has been

A potent inducer of chondrocyte differentiation from human mesenchymal stem cells (EC50 = 100 nM) promotes cartilage repair in a mouse model of osteoarthritis and protects against cytokine-induced damage in osteoarthritic bovine articular

A MS-cleavable crosslinking reagent (18&Aring in length) that contains two intrinsic positive charges, which allow cross-linked peptides to fragment into their component peptides by collision-induced dissociation or in-source decay.

Molecular Formula: C₂₈H₂₄F₃N₇O₂

An analog of cyclopamine that inhibits the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 &muM and dose dependently inhibits platelet aggregation in rabbits ex vivo induces serotonin release and inhibits its re-uptake in the CNS.

C-2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides.