Valproic acid

A physiologically active metabolite of losartan a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation.

Limaprost is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 &microg/kg as an inhibitor of ADP and collagen

A selective COX-2 inhibitor that exhibits IC50 values of 26.1 and 0.87 &microM for COX-1 and COX-2, respectively, in a human whole blood assay.

A conjugated PUFA that induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 &microM) increases the production of ROS, leading to oxidative stress that contributes to cytotoxicity.

3-Pyrimidin-2-yl-Propionic Acid is a synthetic intermediate useful for pharmaceutical synthesis.

Phytanic acid is a saturated 20-carbon branched-chain fatty acid which can only be derived from dietary sources. In cases of peroxisomal disorders, elevated levels of phytanic acid have been observed, and this is linked to diseases such as infantile

An RSV inhibitor that demonstrates antiviral activity with an EC₅₀ value of 1.4 nM interferes directly with RSV fusion (EC₅₀ = 5.4 nM), binding to the viral F protein.

Limaprost is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 &microg/kg as an inhibitor of ADP and collagen

1-Oleoyl LPA is a species of LPA containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of PLD or through a two step process involving liberation of DAG by PLC followed by phosphorylation of DAG

A major urinary metabolite of PGD2 with a unique lower sidechain that readily undergoes reversible cyclization used as a biomarker to assess endogenous production of PGD2.

A LPA analog containing stearyl alcohol at the sn-1 position exhibits platelet aggregating activity with an EC50 value of 9 nM versus an EC50 value of 177 nM for 1-octadecanoyl LPA.

Phytanic acid is a saturated 20-carbon branched-chain fatty acid which can only be derived from dietary sources. In cases of peroxisomal disorders, elevated levels of phytanic acid have been observed, and this is linked to diseases such as infantile