Bicalutamide

A naturally occurring caffeoyl conjugate with antioxidant and antiradical properties demonstrates neuroprotective effects (EC₅₀s = 0.9-3.7 &microM) in several in vitro models of neuronal death.

Inhibitor of NF-&kappaB activation that blocks the phosphorylation of IKK and I&kappaB (IC50 ~ 40 &muM) dose dependently inhibits the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells.

A cell permeable inhibitor of PKC with IC₅₀ values reported to range from 0.10 to 0.

A highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKC&alpha-, &beta1-, &beta2-, &gamma-, &delta-, and

A selective, cell-permeable PKC inhibitor that displays 10-fold greater selectivity for PKC&alpha (IC50 = 9 nM) and 4-fold greater selectivity for PKC&betaI (IC50 = 28 nM) over Ca2+-independent PKC&epsilon (IC50 = 108 nM) prevents T-cell

A bacterial DNA gyrase inhibitor that disrupts supercoiling activity (IC₅₀ = 3.3 &microM) demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs range from 10-80 &microM).

A metabolite of epinephrine produced by the action of catechol-O-methyl transferase on epinephrine detection is used in the clinical diagnosis of pheochromocytoma.

A naturally occurring caffeoyl conjugate with antioxidant and antiradical properties demonstrates neuroprotective effects (EC₅₀s = 0.9-3.7 &microM) in several in vitro models of neuronal death.

An orally bioavailable inhibitor of Smo blocks binding of BODIPY cyclopamine (IC₅₀ = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC₅₀s = 6-35 nM) inhibits Shh

A Gcn5 and pCAF HAT inhibitor.

A reversible inhibitor of both agonist and antagonist binding to diverse GPCRs blocks the binding of radiolabeled ligands to human opioid, adrenergic, muscarinic, dopaminergic, adenosine, and purinergic receptors with IC₅₀ values of 0.1

A sesquiterpene lactone which protects against cerebral edema, decreases cortical infarct volume, and reduces cerebral ischemic damage at 10 &muM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions