Bicalutamide

A non-steroidal antiandrogen that binds the androgen receptor (Ki = 12.5 &muM IC₅₀ = 1.2 &muM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones.

A primary metabolite of nicotinamide produced by the action of NNMT demonstrates antithrombotic and anti-inflammatory properties and may play a role in cancer cell metabolism.

A benzylisoquinoline alkaloid that exhibits antimicrobial, anti-inflammatory, and anti-oxidant properties and demonstrates antiproliferative and pro-apoptotic effects in some cancer cell lines.

An isomer of valpromide that has been marketed as an anxiolytic and sedative compound abolishes the activity of MIP synthase in human brain crude homogenates (Ki = 0.18 mM) suppresses electrographic seizures in animal models of status epilepticus.

SEIT is a potent inhibitor of NOS in vitro but lacks good in vivo efficacy due to poor cellular penetration. The Ki values are 19, 39, and 29 nM using purified human iNOS, eNOS, and nNOS, respectively.

A prodrug for methylprednisolone has superior water solubility compared to the active glucocorticoid.

A widely used synthetic antioxidant found in all types of manufactured items from foodstuff to cosmetics to rubber and paint.

1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human eNOS. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.

SEIT is a potent inhibitor of NOS in vitro but lacks good in vivo efficacy due to poor cellular penetration. The Ki values are 19, 39, and 29 nM using purified human iNOS, eNOS, and nNOS, respectively.

A reagent used for absorbance based measurement of protein. Also known as 4,4&#39-Dicarboxy-2,2&#39-Biquinoline BCA 2,2&#39-Biquinoline-4,4&#39-Dicarboxylate 2,2&#39-Biquinoline-4,4&#39-Dicarboxylic acid Appearance: Colorless to pale yellow

A popular non-cleavable, membrane-impermeable, water-soluble DSS analog Category: Amine-reactive Reactive Groups: sulfo-NHS-ester Reactive Toward: amino grops Water Soluble: Yes Membrane Permeable: No Cleavability: Non-cleavable MW: 572.43

SDF-1 alpha, rMuSDF-1 alpha, CXCL12, murine (mouse): SDF-1&alpha and SDF-1&beta, members of the chemokine &alpha subfamily that lack the ELR domain, were initially identified using the signal sequence trap cloning strategy from a mouse