A nonthiazide diuretic that inhibits the sodium/chloride cotransporter in the distal convoluted tubule of the kidney also effectively inhibits the activity of most platelet carbonic anhydrase isozymes (IC<sub>50</sub>s = 2.8 nM - 11 µM).
A nonthiazide diuretic that inhibits the sodium/chloride cotransporter in the distal convoluted tubule of the kidney also effectively inhibits the activity of most platelet carbonic anhydrase isozymes (IC<sub>50</sub>s = 2.8 nM - 11 µM).