A non-peptide antagonist of PAR1 blocks binding of haTRAP (IC<sub>50</sub> = 70 nM) as well as platelet aggregation induced by either haTRAP or &alpha-thrombin (IC<sub>50</sub> = 0.3 and 3 µM, respectively) has no activity against PAR2,
A non-peptide antagonist of PAR1 blocks binding of haTRAP (IC<sub>50</sub> = 70 nM) as well as platelet aggregation induced by either haTRAP or &alpha-thrombin (IC<sub>50</sub> = 0.3 and 3 µM, respectively) has no activity against PAR2,
A nonthiazide diuretic that inhibits the sodium/chloride cotransporter in the distal convoluted tubule of the kidney also effectively inhibits the activity of most platelet carbonic anhydrase isozymes (IC<sub>50</sub>s = 2.8 nM - 11 µM).
A nonthiazide diuretic that inhibits the sodium/chloride cotransporter in the distal convoluted tubule of the kidney also effectively inhibits the activity of most platelet carbonic anhydrase isozymes (IC<sub>50</sub>s = 2.8 nM - 11 µM).