A loop diuretic with good absorption and pharmacodynamic properties acts as an inhibitor of NKCC1 and the kidney-specific NKCC2 (Ki = 0.5 and 59 &muM for human and rabbit NKCC1, respectively).
A loop diuretic with good absorption and pharmacodynamic properties acts as an inhibitor of NKCC1 and the kidney-specific NKCC2 (Ki = 0.5 and 59 &muM for human and rabbit NKCC1, respectively).
A fluorinated pyrimidine and derivative of fluorouracil that has anti-neoplastic activity and is commonly used as adjuvant therapy following resection for some forms of cancer a potent inhibitor of acid ceramidase (IC<sub>50</sub> = 29 nM).
A fluorinated pyrimidine and derivative of fluorouracil that has anti-neoplastic activity and is commonly used as adjuvant therapy following resection for some forms of cancer a potent inhibitor of acid ceramidase (IC<sub>50</sub> = 29 nM).