2-METHYL-3-BUTYN-2-OL 98% (C005B-009792)

General description

2-Methyl-3-butyn-2-ol (MBY) is used as a precursor in the Mannich reaction and can undergo selective semihydrogenation to produce fine chemicals.

Application

2-Methyl-3-butyn-2-ol can be used as a reactant to synthesize:,·

• Aryl-2-methyl-3-butyn-2-ols via Pd-catalyzed Sonogashira coupling reaction with various aryl bromides.      
• 2-Methyl-3-buten-2-ol (MBE) by Pd/γ-Al₂O₃ catalyzed selective hydrogenation reaction. MBE is applicable as an important intermediate in the synthesis of vitamin A.      
• Diarylacetylenes via Pd-catalyzed Sonogashira coupling reaction with aryl chlorides in the presence of Cs₂CO₃ as a base. 
• Optically active propargylic alcohols by enantioselective addition reaction with various aldehydes in the presence of Zn(OTf)₂ and N-methylephedrine.

Molecular Weight: 84.12. Empirical Formula: C₅H₈O. linearFormula: HC≡. CC(CH₃)₂OH. vapor pressure: 15 mmHg ( 20 °C). Quality Level: 200. Assay: 98%. form: liquid. autoignition temp.: 662 . °F. expl. lim.: 16.6 . %. refractive index: n20/D 1.42 (lit.). bp: 104 . °C (lit.). mp: 2.6 . °C (lit.). density: 0.868 . g/mL . at 25 . °C (lit.). SMILES string: CC(C)(O)C#C. InChI: 1S/C5H8O/c1-4-5(2,3)6/h1,6H,2-3H3. InChI key: CEBKHWWANWSNTI-UHFFFAOYSA-N. Pictograms: GHS02,GHS05,GHS07,GHS08. Signal Word: Danger. Hazard Statements: H225 - H302 - H318 - H336 - H361fd. Precautionary Statements: P202 - P210 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313. Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - STOT SE 3. Target Organs: Central nervous system. Storage Class Code: 3 - Flammable liquids. WGK: WGK 1. Flash Point(F): 68.0 °F. Flash Point(C): 20 °C. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter.