1A-HYDROXYVITAMIN D3 >= 97.0% (HPLC)

General description

1α-Hydroxyvitamin D₃, also known as alfacalcidol, is a synthetic vitamin D₃ analogue, hydroxylated in position one. It is metabolized to 1,25-dihydroxycholecalciferol by 25-hydroxylases.

Biochem/physiol Actions

1α-Hydroxyvitamin D₃ facilitates calcium absorption and deposition. It also has an ability to inhibit bone resorption and stimulate bone formation. Alfacalcidol is used for treating various bone diseases such as rickets/osteomalacia, renal osteodystrophy and osteoporosis. It acts as a chemopreventive agent and reduces the risk colitis and carcinogenesis.

Synthetic vitamin D₃ analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Molecular Weight: 400.64. Empirical Formula: C₂₇H₄₄O₂. biological source: synthetic. Quality Level: 200. Assay: ≥. 97.0% (HPLC). form: powder or crystals. color: white to off-white. storage temp.: −. 20°C. SMILES string: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C): C\C: C3\C[C@@H](O)C[C@H](O)C3: C. InChI: 1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1. InChI key: OFHCOWSQAMBJIW-AVJTYSNKSA-N. Gene Information: human ... VDR(7421). Pictograms: GHS06. Signal Word: Danger. Hazard Statements: H300. Precautionary Statements: P301 + P330 + P331 + P310. Hazard Classifications: Acute Tox. 1 Oral. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges.